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A definitive tissue diagnosis of a vertebral lesion can be made with a minimally invasive, safe, and accurate method called CT-guided percutaneous vertebral biopsy . The most effective substitute for a surgical biopsy is frequently a CT-guided vertebral biopsy. The identification of spinal lesions is mostly dependent on magnetic resonance imaging (MRI). Even while recent advances in MRI now make it possible to recognize and suspect the nature of vertebral lesions and positron emission tomography-computed tomography (PET-CT) provides data on lesion metabolism, a biopsy is still required in the majority of instances. Both open surgery and a less invasive (percutaneous imaging-guided) procedure can be used to confirm the histopathology of a vertebral lesion. An open surgical biopsy of a vertebral lesion has a high risk of morbidity, the potential for contamination of nearby tissue planes, and potential postoperative problems. Under the direction of computed tomography, a percutaneous imag

CT-guided transthoracic needle biopsy is a simple and safe procedure that has a diagnostic accuracy of 64–97 percent for pulmonary lesions (5-8). As a result, one of the most common approaches for diagnosing the nature of pulmonary lesions is to use this process. For precise treatment of advanced non-small-cell lung cancer, molecular investigation of driver mutations is strongly suggested (NSCLC) CT-guided lung biopsy is a relatively safe and well-tolerated treatment. Some patients may endure substantial and long-term discomfort as a result of the treatment, and they should be informed about this beforehand. The doctor will put the needle through the skin, advance it to the site of the nodule, and remove tissue samples using imaging guidance. For a comprehensive analysis, several samples may be required. Following the collection of biopsies, a pathologist will rapidly review the samples to ensure that they are in good condition. When imaging findings indicate stability or when consist